Chronic myeloid leukemia 2010: where are we now and where can we go?

Publication Type:

Journal Article


Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, Volume 2010, p.122-8 (2010)


2010, Center-Authored Paper, Clinical Research Division, Drug Resistance, Neoplasm, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Treatment Outcome


Chronic myeloid leukemia is a model of how the molecular understanding of a disease can provide the platform for therapy and diagnostics. Clinicians are now empowered with first- and second-generation tyrosine kinases, as well as molecular tools to monitor disease and characterize resistance. However, there are still unanswered questions regarding optimization of therapy, the utility of molecular monitoring, and the search (or need) of "cure" that bears thought. In this review, we will discuss these issues, as they provide a roadmap for what may lie ahead in the therapy of other hematologic malignancies, particular the other myeloproliferative syndromes, where specific genetic lesions, and targeted therapy, are now being realized.