Chronic myelogenous leukemia presenting in blast crisis with nodal, bilineal myeloid sarcoma and T-lymphoblastic lymphoma in a child.

Publication Type:

Journal Article


Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2012)


Clinical Research Division, December 2012


Abstract A 14-year-old boy presented with chronic myelogenous leukemia (CML) in blast crisis with segregated extramedullary (nodal) myeloid sarcoma and T lymphoblastic lymphoma. Immunohistochemical stains performed on the lymphadenectomy sample demonstrated T lymphoblasts in the lymph nodes and myeloblasts in the adjacent soft tissue. Fluorescence in situ hybridization (FISH) performed on paraffin sections confirmed both T lymphoblast and myeloblast populations were positive for the t(9;22) BCR/ABL1 translocation. Subsequent flow cytometry analysis of the bone marrow showed expanded populations of abnormal myeloblasts and T lymphoblasts diagnostic of blast crisis CML. To the best of our knowledge, bilineal blast crisis of CML with segregated extramedullary T-lymphoblasts and myeloblasts has not been reported.