Choosing Phase II Endpoints and Designs: Evaluating the Possibilities.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 18, Issue 8, p.2130-2 (2012)

Keywords:

2012, April 2012, Public Health Sciences Division

Abstract:

Selecting the phase II design and endpoint to achieve the best possible chance of success for a confirmatory phase III study in a particular disease and treatment setting is challenging but critical. Simulating from existing clinical trial data sets and from mathematical models can be useful tools for evaluating statistical properties. Clin Cancer Res; 18(8); 2130-2. ©2012 AACR.