Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.

Publication Type:

Journal Article

Authors:

Searles Nielsen, Susan; McKean-Cowdin, Roberta; Farin, Federico M; Holly, Elizabeth A; Preston-Martin, Susan; Mueller, Beth A

Source:

Environmental health perspectives, Volume 118, Issue 1, p.144-9 (2010)

Keywords:

2010, Aldehyde Dehydrogenase, Aryldialkylphosphatase, Brain Neoplasms, Butyrylcholinesterase, Case-Control Studies, Center-Authored Paper, Child, Child, Preschool, Environmental Exposure, Female, Glutathione Transferase, Humans, Infant, Infant, Newborn, Insecticides, Male, Metabolic Detoxication, Drug, Oxygenases, Pesticides, Polymorphism, Single Nucleotide, Public Health Sciences Division, Risk Assessment

Abstract:

Insecticides that target the nervous system may play a role in the development of childhood brain tumors (CBTs). Constitutive genetic variation affects metabolism of these chemicals.