Characterization of T-cell responses to cryptic epitopes in recipients of a noncodon-optimized HIV-1 vaccine.

Publication Type:

Journal Article

Source:

Journal of acquired immune deficiency syndromes (1999), Volume 65, Issue 2, p.142-50 (2014)

Keywords:

2014, AIDS Vaccines, Cohort Studies, Epitopes, T-Lymphocyte, Humans, July 2014, T-Lymphocytes, Vaccine and Infectious Disease Division

Abstract:

Cryptic epitopes (CEs) can be encoded by any of the 5 alternative reading frames (ARFs, 2 sense and 3 antisense) of a known gene. Although CE responses are commonly detected during HIV-1 infection, it is not known whether these responses are induced after vaccination.