Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study.

Publication Type:

Journal Article


PloS one, Volume 4, Issue 4, p.e5272 (2009)


2009, Acyclovir, Adult, Africa, Antiviral Agents, CD4 Lymphocyte Count, Cohort Studies, Female, Follow-Up Studies, Herpes Genitalis, Herpesvirus 2, Human, Heterosexuality, HIV Infections, HIV-1, Humans, Male, RNA, Viral, Sexual Partners, sexually transmitted diseases, Vaccine and Infectious Disease Institute


The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort.