Changes in plasma cytokines after treatment of ascaris lumbricoides infection in individuals with HIV-1 infection.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases, Volume 201, Issue 12, p.1816-21 (2010)

Keywords:

2010, Adult, Albendazole, Animals, Anthelmintics, Ascariasis, Ascaris lumbricoides, Center-Authored Paper, Cytokines, HIV Infections, HIV-1, Human Biology Division, Humans, Immune Tolerance, Placebos, Young Adult

Abstract:

Albendazole treatment of individuals with human immunodeficiency virus type 1 (HIV-1) and Ascaris lumbricoides co-infection has led to significantly improved CD4(+) cell counts and a trend for lower plasma HIV-1 RNA levels in a previous randomized placebo-controlled trial. To define mechanisms by which deworming contributed to changes in markers of HIV-1 disease progression, plasma cytokine levels were evaluated. Albendazole treatment, compared with placebo, was associated with significantly decreased plasma interleukin (IL) 10 levels (P = .01)ot associated with significant changes in levels of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL-13, interferon gamma, tumor necrosis factor alpha, or thymic stromal lymphopoietin. Treatment of A. lumbricoides co-infection may delay HIV-1 disease progression by reducing helminth-induced, IL-10-mediated immunosuppression.