Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial.

Publication Type:

Journal Article


JAMA internal medicine, Volume 175, Issue 2, p.246-54 (2015)


Adenine, Adolescent, Adult, Anti-HIV Agents, Deoxycytidine, Female, HIV Infections, HIV-1, Humans, Kidney Function Tests, Kidney Glomerulus, Male, Medication Adherence, Middle Aged, Organophosphonates, Young Adult


Tenofovir disoproxil fumarate (TDF) use has been associated with declines in the estimated glomerular filtration rate (eGFR) when used as part of antiretroviral treatment by persons with human immunodeficiency virus (HIV) type 1, but limited data are available for risk when used as preexposure prophylaxis (PrEP) for HIV-1 prevention.