Change in lifestyle behaviors and medication use after a diagnosis of ductal carcinoma in situ.

Publication Type:

Journal Article


Breast cancer research and treatment, Volume 124, Issue 2, p.487-95 (2010)


2010, Adult, Aged, Alcohol Drinking, Anti-Inflammatory Agents, Non-Steroidal, Antidepressive Agents, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Center-Authored Paper, Cohort Studies, diet, Estrogen Replacement Therapy, Female, Health Behavior, Health Knowledge, Attitudes, Practice, Humans, Logistic Models, Middle Aged, Neoplasm Recurrence, Local, Odds Ratio, Public Health Sciences Division, Quality of Life, Registries, Risk Assessment, Risk Factors, Risk Reduction Behavior, Smoking Cessation, Survivors, Time Factors, Treatment Outcome, Weight Gain, Wisconsin, Young Adult


Women with ductal carcinoma in situ (DCIS) of the breast represent a growing cancer survivor population with a diagnosis of uncertain malignant potential. These survivors face an absence of scientific guidelines regarding lifestyle changes that can help to prevent a breast cancer recurrence. In this first report from the Wisconsin In Situ Cohort (WISC) study, we examine how women are currently changing their lifestyle behaviors and medication use following a diagnosis of DCIS. At study entry (1997-2006), 1,959 subjects (78% of eligible) with DCIS were identified from the Wisconsin cancer registry and administered an interview assessing behaviors prior to diagnosis. Follow-up interviews were completed every 2 years after the initial interview, beginning in 2003 and continuing through 2006. After adjusting for age and calendar year, women were 2.2 kg (95% CI 1.4, 3.0) heavier, 35% (95% CI 20, 47) less likely to be a smoker, 19% (95% CI -1, 43) more likely to use non-steroidal anti-inflammatory drugs, and 57% (95% CI 26, 95) more likely to use antidepressants after a DCIS diagnosis compared to 1 year prior to diagnosis. Use of postmenopausal hormones decreased sharply (OR = 0.06; 95% CI 0.04, 0.09) following a DCIS diagnosis. These findings indicate that women make substantial changes in their behaviors after a DCIS diagnosis. This cohort will be further monitored to evaluate the association between these behaviors and health outcomes following DCIS.