The challenge of systematic reviews of diagnostic and staging studies in cancer.

Publication Type:

Journal Article


Cancer treatment reviews, Volume 31, Issue 8, p.628-39 (2005)


Diagnosis, Differential, Disease-Free Survival, Endpoint Determination, Humans, Lymphatic Metastasis, Neoplasm Staging, Neoplasms, Odds Ratio, Quality Control, Randomized Controlled Trials as Topic, Research Design, Review Literature as Topic, ROC Curve


Most diagnostic and staging studies focus on test performance characteristics while others may address long term clinical outcomes such as disease-free or overall survival, quality of life or cost. However, controversy remains as to which outcomes to measure and when long term outcomes based on large and costly randomized trials are required.