Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses.

Publication Type:

Journal Article


Virology, Volume 424, Issue 2, p.77-98 (2012)


2012, 257, Alphapapillomavirus, Animals, April 2012, Cell Transformation, Viral, Humans, Oncogene Proteins, Viral, Papillomavirus Infections


The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s yet the mechanisms of virally-mediated cellular transformation are still being revealed. Reasons for this include: a) the oncoproteins are multifunctional, b) there is an ever-growing list of cellular interacting proteins, c) more than one cellular protein may bind to a given region of the oncoprotein, and d) there is only limited information on the proteins encoded by the corresponding non-oncogenic PVs. The perspective of this review will be to contrast the activities of the viral E6 and E7 proteins encoded by the oncogenic human PVs (termed high-risk HPVs) to those encoded by their non-oncogenic counterparts (termed low-risk HPVs) in an attempt to sort out viral life cycle-related functions from oncogenic functions. The review will emphasize lessons learned from the cell culture studies of the HPVs causing mucosal/genital tract cancers.