Cellular immune responses and susceptibility to HIV-1 superinfection: a case-control study.

Publication Type:

Journal Article


AIDS (London, England), Volume 26, Issue 5, p.643-6 (2012)


2012, Apr 2012, April 2012, Center-Authored Paper, Flow Cytometry Core Facility, Genomics Core Facility, Human Biology Division, Shared Resources, Vaccine and Infectious Disease Division


A case-control study was performed to determine the effects of HIV-1-specific cellular immune responses on the odds of acquiring a second HIV-1 infection (superinfection). Changes in the frequency of cytokine-producing or cytolytic CD8+ or CD4+ T cells were not associated with significant alterations in the odds of superinfection, suggesting that HIV-1 specific cellular immune responses at the level induced by chronic infection do not appear to significantly contribute to protection from HIV-1 superinfection.