Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: a long-term prospective study.

Publication Type:

Journal Article


Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 14, Issue 21, p.6988-95 (2008)


2008, ADENOCARCINOMA, Adult, Aged, Barrett Esophagus, cell cycle, Cell Division, Cohort Studies, Esophageal Neoplasms, Female, Genes, p16, Genes, p53, Human Biology Division, Humans, Ki-67 Antigen, Longitudinal Studies, loss of heterozygosity, Male, Middle Aged, Mutation, Prospective Studies, Public Health Sciences Division


Elevated cellular proliferation and cell cycle abnormalities, which have been associated with premalignant lesions, may be caused by inactivation of tumor suppressor genes. We measured proliferative and cell cycle fractions of biopsies from a cohort of patients with Barrett's esophagus to better understand the role of proliferation in early neoplastic progression and the association between cell cycle dysregulation and tumor suppressor gene inactivation.