CDK inhibitors: cell cycle regulators and beyond.

Publication Type:

Journal Article

Source:

Developmental cell, Volume 14, Issue 2, p.159-69 (2008)

Keywords:

2008, Animals, APOPTOSIS, Basic Sciences Division, cell cycle, Cyclin-Dependent Kinase Inhibitor Proteins, Cytoskeleton, Gene Expression Regulation, Humans, Tumor Suppressor Proteins

Abstract:

First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream signaling pathways, the cyclin-CDK inhibitors of the Cip/Kip family p21Cip1, p27Kip1, and p57Kip2 have emerged as multifaceted proteins with functions beyond cell cycle regulation. In addition to regulating the cell cycle, Cip/Kip proteins play important roles in apoptosis, transcriptional regulation, cell fate determination, cell migration and cytoskeletal dynamics. A complex phosphorylation network modulates Cip/Kip protein functions by altering their subcellular localization, protein-protein interactions, and stability. These functions are essential for the maintenance of normal cell and tissue homeostasis, in processes ranging from embryonic development to tumor suppression.