Castration-resistant prostate cancer bone metastasis response measured by 18F-fluoride PET after treatment with dasatinib and correlation with progression-free survival: results from American College of Radiology Imaging Network 6687.

Publication Type:

Journal Article

Source:

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 56, Issue 3, p.354-60 (2015)

Keywords:

Aged, Aged, 80 and over, Antineoplastic Agents, Biopsy, Bone and Bones, Bone Neoplasms, Disease-Free Survival, Fluorine Radioisotopes, Humans, Image Processing, Computer-Assisted, Intervention Studies, Male, Middle Aged, Neoplasm Metastasis, Positron-Emission Tomography, Prostatic Neoplasms, Castration-Resistant, Protein Kinase Inhibitors, Pyrimidines, Receptors, Androgen, Thiazoles, Tomography, X-Ray Computed, Treatment Outcome, Tumor Markers, Biological

Abstract:

(18)F-fluoride PET quantitatively images bone metabolism and may serve as a pharmacodynamic assessment for systemic therapy such as dasatinib, a potent SRC kinase inhibitor, with activity in bone.