Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status.

Publication Type:

Journal Article

Source:

Journal of the National Cancer Institute, Volume 102, Issue 6, p.391-400 (2010)

Keywords:

2010, Adult, African Americans, Aged, Body Mass Index, Case-Control Studies, Center-Authored Paper, Colorectal Neoplasms, Confounding Factors (Epidemiology), Epidemiology Core Facility, European Continental Ancestry Group, Female, Humans, Indians, North American, Life Style, Logistic Models, Male, Microsatellite Instability, Middle Aged, Multivariate Analysis, Obesity, Odds Ratio, Overweight, Public Health Sciences Division, Risk Assessment, Risk Factors, Shared Resources, Specimen Processing Core Facility, Weight Gain

Abstract:

Being overweight or obese is an established risk factor for colorectal cancer, more so for men than for women. Approximately 10%-20% of colorectal tumors display microsatellite instability (MSI), defined as the expansion or contraction of small repeated sequences in the DNA of tumor tissue relative to nearby normal tissue. We evaluated associations between overweight or obesity and colorectal cancer risk, overall and by tumor MSI status.