Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer.

Publication Type:

Journal Article

Source:

International journal of cancer. Journal international du cancer (2010)

Keywords:

2010, Center-Authored Paper, Epidemiology Core Facility, Public Health Sciences Division, Shared Resources, Specimen Processing Core Facility

Abstract:

Cancer risks for a person who has inherited a MUTYH mutation from only one parent (monoallelic mutation carrier) are uncertain. Using the Colon Cancer Family Registry and Newfoundland Familial Colon Cancer Registry, we identified 2,179 first- and second-degree relatives of 144 incident colorectal cancer (CRC) cases who were monoallelic or biallelic mutation carriers ascertained by sampling population complete cancer registries in the USA, Canada and Australia. Using Cox regression weighted to adjust for sampling on family history, we estimated that the country-, age- and sex-specific standardized incidence ratios (SIRs) for monoallelic mutation carriers, compared with the general population, were: 2.04 (95% confidence interval, CI 1.56-2.70; P <0.001) for CRC, 3.24 (95%CI 2.18-4.98; P <0.001) for gastric cancer, 3.09 (95%CI 1.07-12.25; P = 0.07) for liver cancer, and 2.33 (95%CI 1.18-5.08; P = 0.02) for endometrial cancer. Age-specific cumulative risks to age 70 years, estimated using the SIRs and USA population incidences, were: for CRC, 6% (95%CI 5-8%) for men and 4% (95%CI 3-6%) for women; for gastric cancer, 2% (95%CI 1-3%) for men and 0.7% (95%CI 0.5-1%) for women; for liver cancer, 1% (95%CI 0.3-3%) for men and 0.3% (95%CI 0.1-1%) for women; and for endometrial cancer, 4% (95%CI 2-8%). There was no evidence of increased risks for cancers of the brain, pancreas, kidney, lung, breast or prostate. Monoallelic MUTYH mutation carriers with a family history of CRC, such as those identified from screening multiple-case CRC families, are at increased risk of colorectal, gastric, endometrial and possibly liver cancers.