C868T Single Nucleotide Polymorphism and HIV Type 1 Disease Progression Among Postpartum Women in Kenya.

Publication Type:

Journal Article

Source:

AIDS research and human retroviruses (2011)

Keywords:

2011, Center-Authored Paper, October 2011, Public Health Sciences Division, Vaccine and Infectious Disease Division

Abstract:

Abstract The C868T single nucleotide polymorphism in the CD4 receptor encodes an amino acid substitution of tryptophan for arginine in the third domain. Previous studies suggest that C868T increases the risk of HIV-1 acquisition; however, the influence of this single nucleotide polymorphism (SNP) on disease progression has not been established. The presence of the C868T polymorphism was not statistically significantly associated with HIV-1 disease progression outcomes in a cohort of postpartum Kenyan women.