C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients.

Publication Type:

Journal Article


Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 14, Issue 16, p.5260-9 (2008)


2008, Antigens, Neoplasm, Base Sequence, Carcinoma, Renal Cell, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Center-Authored Paper, Chromosomes, Human, Pair 19, Clinical Research Division, Cytokine Analysis Core Facility, Epitopes, T-Lymphocyte, Flow Cytometry Core Facility, Gene Library, hematopoietic stem cell transplantation, HLA-A Antigens, Humans, Immune Monitoring Core Facility, Kidney Neoplasms, Minor Histocompatibility Antigens, Molecular Sequence Data, Polymorphism, Single Nucleotide, Reverse Transcriptase Polymerase Chain Reaction, Shared Resources, Transfection, Transplantation, Homologous


Tumor regression has been observed in some patients with metastatic renal cell carcinoma (RCC) after nonmyeloablative allogeneic hematopoietic cell transplantation (HCT). Cellular and molecular characterization of antigens recognized by tumor-reactive T cells isolated from responding patients could potentially provide insight into the mechanisms of tumor regression.