C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 14, Issue 16, p.5260-9 (2008)

Keywords:

2008, Antigens, Neoplasm, Base Sequence, Carcinoma, Renal Cell, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Center-Authored Paper, Chromosomes, Human, Pair 19, Clinical Research Division, Cytokine Analysis Core Facility, Epitopes, T-Lymphocyte, Flow Cytometry Core Facility, Gene Library, hematopoietic stem cell transplantation, HLA-A Antigens, Humans, Immune Monitoring Core Facility, Kidney Neoplasms, Minor Histocompatibility Antigens, Molecular Sequence Data, Polymorphism, Single Nucleotide, Reverse Transcriptase Polymerase Chain Reaction, Shared Resources, Transfection, Transplantation, Homologous

Abstract:

Tumor regression has been observed in some patients with metastatic renal cell carcinoma (RCC) after nonmyeloablative allogeneic hematopoietic cell transplantation (HCT). Cellular and molecular characterization of antigens recognized by tumor-reactive T cells isolated from responding patients could potentially provide insight into the mechanisms of tumor regression.