Breast cancer after use of estrogen plus progestin in postmenopausal women.

Publication Type:

Journal Article


The New England journal of medicine, Volume 360, Issue 6, p.573-87 (2009)


2009, Aged, Breast Neoplasms, Causality, Center-Authored Paper, Drug Combinations, Estrogen Replacement Therapy, Estrogens, Conjugated (USP), Female, Follow-Up Studies, Humans, Incidence, Mammography, Medroxyprogesterone Acetate, Middle Aged, Postmenopause, Public Health Sciences Division, Risk Factors, United States


Following the release of the 2002 report of the Women's Health Initiative (WHI) trial of estrogen plus progestin, the use of menopausal hormone therapy in the United States decreased substantially. Subsequently, the incidence of breast cancer also dropped, suggesting a cause-and-effect relation between hormone treatment and breast cancer. However, the cause of this decrease remains controversial.