Biodistribution of yttrium-90-labeled anti-CD45 antibody in a nonhuman primate model.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 11, Issue 2 Pt 1, p.787-94 (2005)

Keywords:

Animals, Antibodies, Monoclonal, Antigens, CD45, Bone Marrow, Disease Models, Animal, Immunoconjugates, Lymph Nodes, Macaca nemestrina, Male, Radiation Dosage, Spleen, TISSUE DISTRIBUTION, Yttrium Radioisotopes

Abstract:

Radioimmunotherapy may improve the outcome of hematopoietic cell transplantation for hematologic malignancies by delivering targeted radiation to hematopoietic organs while relatively sparing nontarget organs. We evaluated the organ localization of yttrium-90-labeled anti-CD45 ((90)Y-anti-CD45) antibody in macaques, a model that had previously predicted iodine-131-labeled anti-CD45 ((131)I-anti-CD45) antibody biodistribution in humans.