The Aurora B Kinase Promotes Inner and Outer Kinetochore Interactions in Budding Yeast.

Publication Type:

Journal Article

Source:

Genetics, Volume 194, Issue 3, p.785-9 (2013)

Keywords:

2013, Basic Sciences Division, Center-Authored Paper, Genomics Core Facility, May 2013, Scientific Imaging Core Facility

Abstract:

The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast.