Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma.

Publication Type:

Journal Article

Source:

Cancer epidemiology, Volume 33, Issue 3-4, p.276-80 (2009)

Keywords:

2009, Adult, Aged, Alleles, Case-Control Studies, Center-Authored Paper, Cytochrome P-450 Enzyme System, Dioxins, Epidemiology Core Facility, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Multiple Myeloma, Oxidation-Reduction, Polycyclic Hydrocarbons, Aromatic, Public Health Sciences Division, Risk Factors, Shared Resources

Abstract:

We examined risk of multiple myeloma (MM) associated with variants in genes involved in metabolism and response to exogenous chemicals [cytochrome P450 enzymes (CYP1B1, CYP2C9), epoxide hydrolase (EPHX1), paraoxonase 1 (PON1), arylhydrocarbon hydroxylase receptor (AHR), and NAD(P)H:quinone oxidoreductase (NQO1)].