Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 19, Issue 2, p.537-46 (2010)

Keywords:

2010, Adult, Breast, Center-Authored Paper, Clinical Research Division, Female, Genetic Predisposition to Disease, Glucuronosyltransferase, Humans, Mammography, Middle Aged, Nutrition Assessment Core Facility, Polymorphism, Single Nucleotide, Premenopause, Public Health Sciences Division, Research Trials Office Core Facility - Biostatistics Service, Shared Resources, Sulfotransferases

Abstract:

Sex hormones are metabolized to less active compounds via (a) glucuronidation catalyzed by UDP-glucuronosyltransferases (UGT) and (b) sulfation catalyzed by sulfotransferases (SULT). Functional UGT and SULT polymorphisms can affect clearance of sex hormones, thereby influencing exposure in hormone-sensitive tissues, such as the breast. We assessed relationships between functional polymorphisms in the UGT and SULT genes and breast density in premenopausal women.