Associations Between Colorectal Cancer Molecular Markers and Pathways With Clinicopathologic Features in Older Women.

Publication Type:

Journal Article

Source:

Gastroenterology (2013)

Keywords:

2013, June 2013, Public Health Sciences Division

Abstract:

Colorectal tumors have a large degree of molecular heterogeneity. Three integrated pathways of carcinogenesis (ie, traditional, alternate, and serrated) have been proposed, based on specific combinations of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and mutations in BRAF and KRAS. We used resources from the population-based Iowa Women's Health Study (N = 41,836) to associate markers of colorectal tumors, integrated pathways, and clinical and pathology characteristics, including survival times.