Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.

Publication Type:

Journal Article

Source:

BMC cancer, Volume 8, p.230 (2008)

Keywords:

2008, Adult, Aged, Aged, 80 and over, Genotype, Humans, In Situ Hybridization, Fluorescence, Male, Microarray Analysis, Middle Aged, Oncogene Fusion, Oncogene Proteins, Fusion, Polymorphism, Single Nucleotide, PROSTATECTOMY, Prostatic Neoplasms, Public Health Sciences Division, Treatment Outcome

Abstract:

The presence of the TMPRSS2-ERG fusion gene in prostate tumors has recently been associated with an aggressive phenotype, as well as recurrence and death from prostate cancer. These associations suggest the hypothesis that the gene fusion may be used as a prognostic indicator for prostate cancer.