Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma.

Publication Type:

Journal Article

Source:

Journal of the National Cancer Institute, Volume 101, Issue 21, p.1510-22 (2009)

Keywords:

2009, Adult, Aged, Aged, 80 and over, Antibodies, Viral, Carcinoma, Merkel Cell, Carrier State, Case-Control Studies, Center-Authored Paper, Clinical Research Division, Cloning, Molecular, DNA, Viral, Epidemiology Core Facility, Female, Human Biology Division, Humans, Immunoblotting, Male, Middle Aged, mutagenesis, Nucleic Acid Amplification Techniques, Odds Ratio, Plasmids, Polymerase Chain Reaction, Polyomavirus Infections, Public Health Sciences Division, Shared Resources, Skin Neoplasms, Specimen Processing Core Facility, Tumor Virus Infections

Abstract:

Merkel cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association between these antibodies and Merkel cell carcinoma.