Association of megalin genetic polymorphisms with prostate cancer risk and prognosis.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 14, Issue 12, p.3823-31 (2008)

Keywords:

2008, Adult, Case-Control Studies, Center-Authored Paper, DISEASE PROGRESSION, Gene Frequency, Genetic Predisposition to Disease, Genotype, Human Biology Division, Humans, LDL-Receptor Related Protein 2, Male, Middle Aged, Polymorphism, Single Nucleotide, Prognosis, Prostatic Neoplasms, Public Health Sciences Division, RECURRENCE, Research Trials Office Core Facility - Biostatistics Service, Risk Factors, Shared Resources, Specimen Processing Core Facility

Abstract:

Megalin, an endocytic receptor expressed by prostate epithelial cells, can internalize biologically active androgens bound to sex hormone binding globulin. Genetic variation within megalin could potentially influence levels of steroid hormone uptake.