Association of megalin genetic polymorphisms with prostate cancer risk and prognosis.

Publication Type:

Journal Article


Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 14, Issue 12, p.3823-31 (2008)


2008, Adult, Case-Control Studies, Center-Authored Paper, DISEASE PROGRESSION, Gene Frequency, Genetic Predisposition to Disease, Genotype, Human Biology Division, Humans, LDL-Receptor Related Protein 2, Male, Middle Aged, Polymorphism, Single Nucleotide, Prognosis, Prostatic Neoplasms, Public Health Sciences Division, RECURRENCE, Research Trials Office Core Facility - Biostatistics Service, Risk Factors, Shared Resources, Specimen Processing Core Facility


Megalin, an endocytic receptor expressed by prostate epithelial cells, can internalize biologically active androgens bound to sex hormone binding globulin. Genetic variation within megalin could potentially influence levels of steroid hormone uptake.