Association of hepsin gene variants with prostate cancer risk and prognosis.

Publication Type:

Journal Article

Authors:

Holt, Sarah K; Kwon, Erika M; Lin, Daniel W; Ostrander, Elaine A; Stanford, Janet L

Source:

The Prostate, Volume 70, Issue 9, p.1012-9 (2010)

Keywords:

2010, Adult, Aged, Alleles, Case-Control Studies, Center-Authored Paper, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Prognosis, Proportional Hazards Models, Prostatic Neoplasms, Public Health Sciences Division, Regression Analysis, Risk Assessment, SEER Program, Serine Endopeptidases, Shared Resources, Specimen Processing Core Facility

Abstract:

Hepsin (HPN) is one of the most consistently overexpressed genes in prostate cancer and there is some evidence supporting an association between HPN gene variants and prostate cancer risk. We report results from a population-based case-control genetic association study for six tagging single nucleotide polymorphisms (tagSNPs) in the HPN gene.