Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 24, Issue 3, p.512-9 (2015)

Keywords:

Epidemiology Core Facility, Scientific Imaging Core Facility

Abstract:

The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread aberrant DNA hypermethylation at select CpG islands. The risk factors and environmental exposures contributing to etiologic heterogeneity between CIMP and non-CIMP tumors are not known.