Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot study.

Publication Type:

Journal Article

Source:

Pancreas, Volume 38, Issue 6, p.631-7 (2009)

Keywords:

2009, Aged, Alleles, Amino Acid Substitution, Case-Control Studies, Center-Authored Paper, Cohort Studies, Female, Genetic Variation, Haplotypes, Heterozygote, Homozygote, Humans, Male, Middle Aged, Pancreatic Neoplasms, Pilot Projects, Polymorphism, Single Nucleotide, PPAR gamma, Public Health Sciences Division, Risk Factors, Shared Resources, Smoking, Specimen Processing Core Facility

Abstract:

The Pro12Ala variant in the peroxisome proliferator-activated receptor gamma (PPARG) gene has been associated with diabetes and several cancers. This pilot study tested for the association between Pro12Ala and pancreatic cancer risk in a high-risk sample of smokers.