Association between Cellular Immune Activation, Target Cell Frequency, and Risk of Human Immunodeficiency Virus Type-1 Superinfection.

Publication Type:

Journal Article

Source:

Journal of virology, Volume 88, Issue 10, p.5894-9 (2014)

Keywords:

2014, April 2014, Center-Authored Paper, Flow Cytometry Core Facility, Human Biology Division, Shared Resources, Vaccine and Infectious Disease Division

Abstract:

We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation.