Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction.

Publication Type:

Journal Article

Source:

The American journal of gastroenterology, Volume 104, Issue 8, p.1913-21 (2009)

Keywords:

2009, ADENOCARCINOMA, Adult, Age Factors, Aged, Aged, 80 and over, Center-Authored Paper, Clinical Research Division, Esophageal Neoplasms, Esophagogastric Junction, Female, Humans, Male, Middle Aged, Obesity, Prevention Center Core Facility, Risk Assessment, Risk Factors, Shared Resources, Specimen Processing Core Facility, Young Adult

Abstract:

Adenocarcinomas of the esophagus and adenocarcinomas of the gastroesophageal junction are postulated to be complex genetic diseases. Combined influences of environmental factors and genetic susceptibility likely influence the age at which these cancers develop. The aim of this study was to determine whether familiality and other recognized risk factors are associated with the development of these cancers at an earlier age.