Assessing lead time of selected ovarian cancer biomarkers: a nested case-control study.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 102, Issue 1, p.26-38 (2010)


2010, Adult, Aged, Antigens, CD80, Area Under Curve, CA-125 Antigen, Case-Control Studies, Center-Authored Paper, Epididymal Secretory Proteins, Extracellular Matrix Proteins, Female, GPI-Linked Proteins, Humans, Immunoassay, Membrane Glycoproteins, Middle Aged, Neoplasm Proteins, Ovarian Neoplasms, Predictive Value of Tests, Public Health Sciences Division, Receptors, Tumor Necrosis Factor, Member 6b, Risk Assessment, Risk Factors, ROC Curve, Time Factors, Tumor Markers, Biological


CA125, human epididymis protein 4 (HE4), mesothelin, B7-H4, decoy receptor 3 (DcR3), and spondin-2 have been identified as potential ovarian cancer biomarkers. Except for CA125, their behavior in the prediagnostic period has not been evaluated.