Antiviral Activity of Genital Tract Secretions following Oral or Topical Tenofovir Pre-exposure Prophylaxis for HIV-1.

Publication Type:

Journal Article

Source:

Journal of acquired immune deficiency syndromes (1999) (2014)

Keywords:

2014, February 2014, Public Health Sciences Division, Vaccine and Infectious Disease Division

Abstract:

Surrogate markers of HIV-1 pre-exposure prophylaxis (PrEP) and microbicide efficacy are needed. One potential surrogate is the antiviral activity in cervicovaginal lavage (CVL) after exposure to candidate products. We measured CVL antiviral activity in women using oral or vaginal tenofovir-based PrEP and correlated activity with drug and immune mediator levels.