Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases, Volume 200, Issue 9, p.1452-5 (2009)

Keywords:

2009, Adult, Antibodies, Viral, Exudates and Transudates, Female, Human Biology Division, Human papillomavirus 16, Humans, Immunization, Secondary, Immunoglobulin G, Mouth Mucosa, Papillomavirus Vaccines, Randomized Controlled Trials as Topic, ROC Curve

Abstract:

We sought to determine whether oral fluid can be used to assess serum human papillomavirus (HPV) antibody status by enrolling women who had received a prophylactic HPV-16 vaccine in a new follow-up study. After the prophylactic HPV-6/11/16/18 vaccine was licensed in the United States, we administered it to consenting participants. With serologic findings used as the reference standard, The sensitivity of oral fluid was 49.6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future.