Antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity does not correlate with risk of HIV-1 superinfection.

Publication Type:

Journal Article

Authors:

Forthal, Donald N; Landucci, Gary; Chohan, Bhavna; Richardson, Barbra A; Scott McClelland, R; Jaoko, Walter; Blish, Catherine; Overbaugh, Julie

Source:

Journal of acquired immune deficiency syndromes (1999) (2013)

Keywords:

Center-Authored Paper, Clinical Research Division, February 2013, Vaccine and Infectious Disease Division

Abstract:

ABSTRACT: Previous studies of HIV-infected women with high risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.