Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes.

Publication Type:

Journal Article

Source:

PloS one, Volume 5, Issue 4, p.e10254 (2010)

Keywords:

2010, Center-Authored Paper, Public Health Sciences Division

Abstract:

The V3 loop of the HIV-1 envelope (Env) glycoprotein gp120 was identified as the "principal neutralizing domain" of HIV-1, but has been considered too variable to serve as a neutralizing antibody (Ab) target. Structural and immunochemical data suggest, however, that V3 contains conserved elements which explain its role in binding to virus co-receptors despite its sequence variability. Despite this evidence of V3 conservation, the ability of anti-V3 Abs to neutralize a significant proportion of HIV-1 isolates from different subtypes (clades) has remained controversial.