Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model.

Publication Type:

Journal Article

Source:

Blood, Volume 121, Issue 18, p.3759-67 (2013)

Keywords:

2013, Biologics Production Core Facility, Cell Processing Core Facility, Center-Authored Paper, Clinical Research Division, Comp Med Small Animal, Comparative Medicine Core Facility, Flow Cytometry Core Facility, Genomics Core Facility, Immune Monitoring Core Facility, March 2013, Scientific Imaging Core Facility

Abstract:

Key points Astatination of anti-CD45 antibody via a closo-decaborate compound yields a stable conjugate that targets radiation to hematologic organs.(211)At-anti-CD45 radioimmunotherapy, combined with bone marrow transplantation, prolongs survival in a disseminated murine leukemia model.