Anti-CD28 Antibody-Initiated Cytokine Storm in Canines.

Publication Type:

Journal Article

Source:

Transplantation direct, Volume 1, Issue 2 (2015)

Keywords:

Biologics Production Core Facility, Comparative Medicine Core Facility, Experimental Histopathology Core Facility, Flow Cytometry Core Facility, Proteomics Core Facility

Abstract:

CD28 signal blockade following T cell receptor activation is under intense investigation as a tolerance-inducing therapy for transplantation. Our goal is to produce a CD28-specific reagent as a therapy for the prevention of graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT).