Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: tools for allogeneic transplantation.

Publication Type:

Journal Article

Authors:

Graves, Scott S; Stone, Diane M; Loretz, Carol; Peterson, Laura J; Lesnikova, Marina; Hwang, Billanna; Georges, George E; Nash, Richard; Storb, Rainer

Source:

Transplantation, Volume 91, Issue 8, p.833-40 (2011)

Keywords:

2011, Animals, Antibodies, Monoclonal, Antibody Development Core Facility, Antigens, CD, Antigens, CD28, Binding Sites, Antibody, Biologics Production Core Facility, Cell Proliferation, Center-Authored Paper, Clinical Research Division, Comparative Medicine Core Facility, Dogs, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Flow Cytometry Core Facility, Genomics Core Facility, Graft Rejection, Hybridomas, Immune Monitoring Core Facility, Lymphocyte Activation, Lymphocyte Culture Test, Mixed, MICE, Organ Transplantation, Recombinant Fusion Proteins, Shared Resources, T-Lymphocytes, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Regulatory, Time Factors, Transplantation, Homologous

Abstract:

It has been presumed that antibody-mediated selective costimulatory molecule blockade of CD28 is superior to cytotoxic T lymphocyte antigen 4 (CTLA4)-Ig. This is based on the premise that specifically blocking CD28 allows inhibitory signals through CTLA-4 to proceed, which furthermore suppresses T-cell function.

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