Androgen receptor variants occur frequently in castration resistant prostate cancer metastases.

Publication Type:

Journal Article


PloS one, Volume 6, Issue 11, p.e27970 (2011)


2011, December 2011, Human Biology Division


Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Since specific antibodies detecting all C-terminal truncated AR variants are not available, our aim was to develop an approach to assess the prevalence and function of AR variants in prostate cancer (PCa).