Androgen receptor variants occur frequently in castration resistant prostate cancer metastases.

Publication Type:

Journal Article

Source:

PloS one, Volume 6, Issue 11, p.e27970 (2011)

Keywords:

2011, December 2011, Human Biology Division

Abstract:

Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Since specific antibodies detecting all C-terminal truncated AR variants are not available, our aim was to develop an approach to assess the prevalence and function of AR variants in prostate cancer (PCa).