Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias.

Publication Type:

Journal Article


Clinical chemistry, Volume 54, Issue 1, p.44-52 (2008)


2008, Algorithms, Bias (Epidemiology), Blood Specimen Collection, Decision Support Techniques, Humans, Male, Middle Aged, Predictive Value of Tests, Prostatic Hyperplasia, Prostatic Neoplasms, PROTEOMICS, Public Health Sciences Division, ROC Curve, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tumor Markers, Biological


This report and a companion report describe a validation of the ability of serum proteomic profiling via SELDI-TOF mass spectrometry to detect prostatic cancer. Details of this 3-stage process have been described. This report describes the development of the algorithm and results of the blinded test for stage 1.