AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer risk.

Publication Type:

Journal Article

Source:

The Prostate, Volume 71, Issue 5, p.498-506 (2011)

Keywords:

2011, Adult, Aged, Case-Control Studies, Dairy Products, diet, Dietary Fats, DNA, Genetic Variation, Genotype, Humans, Male, Meat, Middle Aged, Phytanic Acid, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Public Health Sciences Division, Questionnaires, Racemases and Epimerases, Regression Analysis, Washington

Abstract:

Alpha-methylacyl CoA racemase (AMACR) is an enzyme involved in fatty acids metabolism. One of AMACRs primary substrates, phytanic acid, is principally obtained from dietary red meat/dairy, which are associated with prostate cancer (PCa) risk. AMACR is also a tumor tissue biomarker over-expressed in PCa. In this study, we explored the potential relationship between AMACR polymorphisms, red meat/dairy intake, and PCa risk.