Alpha-momorcharin possessing high immunogenicity, immunotoxicity and hepatotoxicity in SD rats.

Publication Type:

Journal Article

Source:

Journal of ethnopharmacology, Volume 139, Issue 2, p.590-8 (2012)

Keywords:

Anaphylaxis, Animals, Antibodies, Biological Markers, Biopsy, Bone Marrow Cells, Bone Marrow Examination, Dose-Response Relationship, Drug, Drug-Induced Liver Injury, Enzyme-Linked Immunosorbent Assay, Female, Guinea Pigs, liver, Liver Function Tests, Male, Maximum Tolerated Dose, Momordica charantia, Necrosis, Passive Cutaneous Anaphylaxis, Plant Extracts, Plants, Medicinal, Rats, Rats, Sprague-Dawley, Ribosome Inactivating Proteins, Seeds, T-Lymphocyte Subsets, Time Factors, Toxicity Tests, Weight Loss

Abstract:

Momordica charantia L., a genus of Momordica Linn. of the family Cucurbitaceae, commonly known as bitter melon, has been widely planted in China, Southeast Asia, Turkey and other areas, and has been used as a medicine for a long time. Alpha-momorcharin (α-MMC) extracted and purified from bitter melon seeds has significant anti-tumor and anti-virus effects, and has potential toxicity as well, especially when taken overdose. However, up to date studies on its safety evaluation are still insufficient.