Alpha Imaging Confirmed Efficient Targeting of CD45-Positive Cells after Astatine-211 (211At)-Radioimmunotherapy for Hematopoietic Cell Transplantation.

Publication Type:

Journal Article

Source:

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 56, Issue 11, p.1766-73 (2015)

Keywords:

Biologics Production Core Facility, Collaborative Data Services, Comparative Medicine Core Facility, Experimental Histopathology Core Facility, Flow Cytometry Core Facility, Genomics Core Facility, Immune Monitoring Core Facility, Proteomics Core Facility, Scientific Imaging Core Facility

Abstract:

Alpha-radioimmunotherapy targeting CD45 may substitute for total body irradiation in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma. Our goal was to optimize the anti-CD45 monoclonal antibody (MAb; CA12.10C12) protein dose for astatine-211 ((211)At)-radioimmunotherapy, extending the analysis to include intra-organ (211)At activity distribution and α-imaging-based small-scale dosimetry, along with immunohistochemical staining.