Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma.

Publication Type:

Journal Article


Gastroenterology, Volume 137, Issue 1, p.110-8 (2009)


2009, Academic Medical Centers, Aged, alpha-Fetoproteins, Biological Markers, Carcinoma, Hepatocellular, Case-Control Studies, Center-Authored Paper, Early Detection of Cancer, Female, Humans, Lectins, Liver Neoplasms, Male, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Protein Precursors, Prothrombin, Public Health Sciences Division, ROC Curve, Sensitivity and Specificity, Tumor Markers, Biological, United States


Alpha-fetoprotein (AFP) is widely used as a surveillance test for hepatocellular carcinoma (HCC) among patients with cirrhosis. Des-gamma carboxy-prothrombin (DCP) and lectin-bound AFP (AFP-L3%) are potential surveillance tests for HCC. The aims of this study were to determine performance of DCP and AFP-L3% for the diagnosis of early HCC; whether they complement AFP; and what factors affect DCP, AFP-L3%, or AFP levels.