AIDSVAX immunization induces HIV-specific CD8+ T-cell responses in high-risk, HIV-negative volunteers who subsequently acquire HIV infection.

Publication Type:

Journal Article

Source:

Vaccine, Volume 27, Issue 7, p.1136-40 (2009)

Keywords:

2009, Adolescent, Adult, AIDS Vaccines, CD8-Positive T-Lymphocytes, Center-Authored Paper, Disease Susceptibility, Europe, HIV Infections, Human Experimentation, Humans, Middle Aged, Public Health Sciences Division, United States, Vaccine and Infectious Disease Institute, Viremia, Young Adult

Abstract:

Correlates of immune protection from HIV vaccines remain undefined. The first HIV vaccine efficacy trial in the US and Europe VAX004, was designed to assess whether rgp120 envelope subunits (AIDSVAX B/B, VaxGen) can induce partial or complete protection from HIV-1 infection. No effectiveness in the reduction of either the acquisition of infection or levels of plasma viremia after HIV infection was noted. We found evidence of vaccine-specific CD8+ T cells in volunteers who received the vaccine, regardless of behavioral risk. Surprisingly, the CD8-response is significantly higher in participants who would go on to contract HIV infection. These results suggest that AIDSVAX immunization may boost preexisting immune responses-due to pre-infection exposure, and a vaccine-induced immune profile may serve as a biological marker for HIV susceptibility.