Advances and challenges in the treatment of glioblastoma: a clinician's perspective.

Publication Type:

Journal Article


Discovery medicine, Volume 15, Issue 83, p.221-30 (2013)


2013, Antineoplastic Agents, Brain, Brain Neoplasms, Clinical Research Division, Clinical Trials as Topic, Disease-Free Survival, Glioblastoma, Glioma, Humans, Magnetic Resonance Imaging, October 2013, Quality of Life, RECURRENCE, Signal Transduction, Treatment Outcome


Glioblastoma (GBM) is the most deadly form of human cancer. Most patients diagnosed with this WHO grade IV malignant glioma survive about 12 months. Despite international efforts, treatment of GBM remains one of the most challenging tasks in clinical oncology. While new molecular pathways active in the biology and invasiveness of glioma are being constantly discovered, translation of basic science achievements into clinical practice is rather slow. Advances in surgical approaches, radiotherapy, and chemotherapy are contributing to incremental improvements in survival of the patients with GBM and improved quality of life. Yet much more significant strides need to be made before we can witness positive outcomes, similar to those seen in certain other cancers that can now be treated successfully. This review will discuss standard of care approach to GBM therapy in a newly diagnosed and recurrent setting. It will summarize the recent developments in management of this disease as well as future directions, keeping a practicing clinician in mind.