Adjuvant chemotherapy in older women with early-stage breast cancer.

Publication Type:

Journal Article


The New England journal of medicine, Volume 360, Issue 20, p.2055-65 (2009)


2009, Aged, Aged, 80 and over, Antimetabolites, Antineoplastic, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Chemotherapy, Adjuvant, Cisplatin, Cyclophosphamide, Deoxycytidine, Doxorubicin, Female, Fluorouracil, Humans, Kaplan-Meier Estimate, Male, methotrexate, Neoplasm Metastasis, Neoplasm Recurrence, Local, Neoplasm Staging, Public Health Sciences Division, Receptors, Estrogen, Survival Analysis


Older women with breast cancer are underrepresented in clinical trials, and data on the effects of adjuvant chemotherapy in such patients are scant. We tested for the noninferiority of capecitabine as compared with standard chemotherapy in women with breast cancer who were 65 years of age or older.